I stayed here for one night (not through choice) and I was very impressed with the hotel.It's a clean modern hotel and the rooms were the best that I had come across in the region.Very roomy and excellent bathroom.I had breakfast and dinner here and again I had no complaints whatsoever the breakfast in particular was very good.
I suppose the slight downside is that it is outside the main part of the town (the old quarter,cafe area etc).It took about 20 minutes to walk (very safe even at night) or a short taxi ride.Since taxis are cheap in Skopje this wasn't a particular hardship.Skopje has a very nice centre and is well worth a visit for a few days.I would have no hesitation in recommending this hotel.I know that there are hotels closer to the centre but you could do far worse than this hotel.All in all a very good experience and as one of your other contributors has commented I am surprised that it isn't higher up the list for Skopje.Quite possibly the reason for this is that I gather that the hotel has not been open that long (3 years I believe) and since Skopje isn't exactly on the tourist route the hotels don't get that many reviews

Hotel Karpos is a good hotel, reasonably central and has very spacious, comfortable rooms.

The rooms are clean, have decent bathrooms (with both bath and shower), plenty of seating and desk space, comfortable beds and, importantly, WiFi throughout the hotel (€8/day, but well worth it, and proper broadband too).

The restaurant is nice, if quiet, with a nice terrace outside. Food is good, and you're close (15 minute walk) to the central eating/drinking area in Skopje, which runs between the Holiday Inn and the Stone Bridge.

All in all, a good hotel by general standards, and a very good hotel in comparison to the others Skopje has to offer. Worth much more than its current ranking on Trip Advisor.

I must share this: I tried to find a room where I could feel relaxed after a cousy and stressed working day, and I`ve looking around in every Skopje hotel. But non of the rooms fit my luggage from the States, no place for my personnal guests, no in-room kitchen facilities....and finally, a colleague of mine, explained me that a recently opened hotel is offering all this facilities. Went there to check it out-the next thing I know, I was moved over there and ended up for 3 months.
Thanks God, someone realized that a different and more comfortable hotel is required in Skopje!