Incan majesty and Andean baroque exist side-by-side in Cusco's stone streets, epitomized by the Qoriacancha palace and the church of Santo Domingo flanking the Plaza de Armas. In this high-altitude melting pot of Amerindian and mestizo culture, you'll find extraordinary textiles, lively summer festivals and archaeological wonders.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Frequented by A-listers and ranked as one of Los Angeles’ trendiest enclaves, West Hollywood is known for its nightlife, upscale shopping areas, destination restaurants, and live-entertainment venues. The area's famed thoroughfares include Sunset Strip and Melrose Avenue.