U.S. citizens still need to jump through a few hoops to visit Cuba, but as visitors from around the world know, this island offers some amazing opportunities for cultural exchange. Havana is a mix of old-world architecture and of-the-moment culture. Head out of the capital city to the small town of Trinidad to see more Spanish colonial architecture. It’s a UNESCO World Heritage Site and a fantastic home base for a visit to the Valley of the Sugar Mills, a pocket of land that formerly served as the centre of Cuba’s sugar industry.

Chiriquí Province is a mountainous wonderland, located near the Barú Volcano. If you’re an adventure and nature lover, you’ll be right at home here, as the region offers everything from white-water rafting and kayaking to zip-line rainforest rides and hiking. More relaxed activities, such as coffee plantation tours and bird-watching, also are available here. To reach Chiriquí, you’ll likely pass through David, Panama’s third-largest city. If you choose to visit the Gulf of Chiriquí, you’ll find first-rate scuba diving, snorkeling, and other water sports that take full advantage of its marine location.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Miles of white sand and romantic island resorts beckon from the hem of the Palmetto State. Families gravitate to Myrtle Beach and the 60- mile span of Grand Strand, where over 100 championship golf courses, tennis courts and nightclubs await. Charleston's hundreds of heritage buildings and irresistible charm are part of its allure. Beach resorts at Kiawah Island, Seabrook and Edisto Island make for romantic getaways. Marshes, moss-bearded palms and oak groves create a haunting atmosphere in the Lowcountry.

It's a historic capital. It's a beach resort. It's a lively, romantic town. Whatever you look for in a Mexican holiday is on the menu in Mazatlan. Returning travellers rave about the welcoming Mazatlecos who treat you like old amigos—as well as the beaches, the food, the weather, the music and the feeling of never wanting to leave.