The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

Many people travel through Frankfurt for business, as it's a major transportation hub and an industrial and financial metropolis. Of course we know that business travellers hate to have any fun on the road (wink), but it's worth lingering in Frankfurt if you can. The 2,000-year-old city has much to offer: skyscrapers, the Main River, a famous opera house, thriving theatre district, zoo, pedestrian shopping street, parks, scores of bars and dance clubs, and more than 50 museums.

If you’re after a winter sports holiday, you can’t find a more gorgeous place to do it than Interlaken, the popular Swiss resort town. There’s superlative skiing, toboggan rides, miles of sledding tracks (which, like the ski slopes, vary in difficulty), snowboarding… all with amazing views of the mountains. In summer, hike among the ibex at nearby Neiderhorn, or shop for watches in the town’s boutiques.

When most people think of Zermatt, they think of one thing: The Matterhorn. This ultimate Swiss icon looms over Zermatt, first drawing visitors here in the 1860s. The village of Zermatt itself is lovely and car-free, with old-fashioned brown chalets and winding alleys. (Don’t worry, you don’t have to walk everywhere—there are electric vehicles and horse-drawn cabs.) Skiing in the region often lasts through early summer, but when the weather’s warmer, it’s a great time to hike.

Relaxed beaches flank the sunny resort town of Menton, known as "the pearl of France," and its most temperate locale. Nearly a dozen private beaches offer bar service and lounge chairs. The free public beaches are kid-friendly with plenty of aquatic sports to inspire a plunge into the Med.

One of the most popular regions in Italy, Tuscany stretches from the Tyrrhenian Sea to the Apennines. Its main cities include Florence, Pisa, Siena, Lucca, Arezzo and Livorno. Drive between stunning sites like Florence's cathedral and Uffizi Gallery and the Leaning Tower of Pisa. Or join a bike tour and pedal past sun-baked olive groves and vineyards. Don't miss the towers of San Gimignano or serene northern hill towns. For a more modern take, hit one of Florence's hip clubs, such as Space Electronic.

Over 15 million gallons of water bubble daily into Budapest's 118 springs and boreholes. The city of spas offers an astounding array of baths, from the sparkling Gellert Baths to the vast 1913 neo-baroque Szechenyi Spa to Rudas Spa, a dramatic 16th-century Turkish pool with original Ottoman architecture. The "Queen of the Danube" is also steeped in history, culture and natural beauty. Get your camera ready for the Roman ruins of the Aquincum Museum, Heroes' Square and Statue Park, and the 300-foot dome of St. Stephen's Basilica.