Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

The Red River is the heart and soul of Shreveport, a cultural and gaming centre on the Louisiana/Texas border. Riverboat casinos evoke the glamour and mystery of the past while providing modern travellers with thrills and excitement. If the tables aren't your style, take a trip over the neon-lit Texas Street Bridge to the horse-racing at Louisiana Downs in Bossier City, Shreveport's thriving sister city. Visitors can unwind in one of Shreveport's botanical oases and enjoy the area's fine waterfront dining, shopping and entertainment. Shreveport sizzles in the summertime but has a temperate climate for the rest of the year.

It's a historic capital. It's a beach resort. It's a lively, romantic town. Whatever you look for in a Mexican holiday is on the menu in Mazatlan. Returning travellers rave about the welcoming Mazatlecos who treat you like old amigos—as well as the beaches, the food, the weather, the music and the feeling of never wanting to leave.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

From family-friendly activities to professional sports, museums and galleries, Rochester has something for everyone. Enjoy the scenic Erie Canal, Genesee River and Lake Ontario. Don't miss the Strong National Museum of Play (America's second-largest children's museum) or the International Museum of Photography. Be sure to sample one of Rochester's famous ‘white hots’, Rochester's version of the hotdog! And don't miss the nearby Finger Lakes region, with its wine trails and gorges.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.