Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Modern myth has it that these days everyone in Los Angeles has written a screenplay, is writing a screenplay or is just visiting. For those in the latter category we offer a road map of ideas to help make a trip to this ultra-hip, ultra-happening haven easy, fun and exciting. While LA will always be associated with movies and movie stars, it is also a culturally vibrant city that boasts a range of interesting attractions from prestigious art museums and galleries to fabulous theatre, both well-known productions and smaller fringe shows. Art enthusiasts will be stunned by the extensive collections at the J. Paul Getty Center and the Los Angeles County Museum of Art. Visit the La Brea Tar Pits on Museum Row, then investigate the trendy shops on Melrose Avenue. Families will not want to miss the zoo or the action at Universal Studios Hollywood. Of course, no trip to LA would be complete without a stop at the Venice Beach Boardwalk or a visit to Mann's Chinese Theater and the Walk of Fame.

Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

What happens when a "gassy" Englishman rows into town feeling thirsty? A pub is born. And from that a city—in this case Vancouver. Though the pubs are plentiful, food and drink aren’t the only things to take in during your trip. In its 150 years, Vancouver has grown into a cosmopolitan city nestled in the great outdoors. Enjoy the snow-capped mountains, waterfront forests, cityside beaches, Olympic history and the world’s highest suspension bridge. Hipsters welcome. (Don’t worry, they don’t bite.)

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Known as New York's tough neighbour with a major international airport, Newark is a destination in its own right. The city is undergoing revitalisation efforts and its attractions include several large parks, art galleries and architecturally significant buildings. The Newark Museum is a complex of art and science exhibits, a mini-zoo, a planetarium and more. Theatre, music and dance performances take place at venues such as the New Jersey Performing Arts Center and Newark Symphony Hall.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Iceland’s biggest city, Reykjavik bears the distinction of being the world’s northernmost capital, and for virtually every Icelandic visitor it serves as a gateway, just to the city itself or to the rugged adventure options beyond. Founded in the country’s southwest at the end of the 18th century, Reykjavik has been Iceland’s cultural hub ever since. These days, that culture includes a hip and internationally recognised music and arts scene, not to mention a notoriously wild nightlife.