Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Modern myth has it that these days everyone in Los Angeles has written a screenplay, is writing a screenplay or is just visiting. For those in the latter category we offer a road map of ideas to help make a trip to this ultra-hip, ultra-happening haven easy, fun and exciting. While LA will always be associated with movies and movie stars, it is also a culturally vibrant city that boasts a range of interesting attractions from prestigious art museums and galleries to fabulous theatre, both well-known productions and smaller fringe shows. Art enthusiasts will be stunned by the extensive collections at the J. Paul Getty Center and the Los Angeles County Museum of Art. Visit the La Brea Tar Pits on Museum Row, then investigate the trendy shops on Melrose Avenue. Families will not want to miss the zoo or the action at Universal Studios Hollywood. Of course, no trip to LA would be complete without a stop at the Venice Beach Boardwalk or a visit to Mann's Chinese Theater and the Walk of Fame.

Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Queens is the most ethnically diverse area of its size on Earth, which means there's a little something for everyone. Chow down on Indian food, sit in on a traditional Irish pub music session, and dance the night away at a Puerto Rican nightclub, all of it located within a few subway stops. Queens is also the home of the Mets and the US Tennis Open, and the former home of the New York World's Fair, now Flushing Meadow-Corona Park, and Paramount Pictures, now the Museum of the Moving Image.

Quebec City may be the only fortified city north of Mexico, but it welcomes visitors with open arms. Explore the Citadel, where you might catch Canadian troops staging a military ceremony. As for food, you could splurge on afternoon tea at the Chateau Frontenac, or do as the locals do and snack on poutine—french fries with gravy and cheese curds.

Once infamous for dangerous gangs and drug activity, Medellin has been transformed. It’s now a vibrant destination for travelers seeking a culturally rich vacation. Medellin rises proudly from the belly of the Aburrá Valley, and its natural beauty makes a perfect setting for hiking, zip lining and horseback riding. Travel through lush jungle to Piedra de Penol, then climb the 740 steps to the top—a journey within a journey that rewards you with unforgettable views.

Edinburgh is Scotland’s capital city, renowned for its heritage, culture and festivals. Take a long walk around the centre to explore the World Heritage Sites of the Old Town and New Town, as well as all the area’s museums and galleries. Then stop for a delicious meal made from fresh Scottish produce before heading out to take in one of Edinburgh’s many events — including the famous summer festivals of culture, or the Winter Festivals of music, light and ceilidhs.