A bustling urban center in quiet New England, Manchester, New Hampshire combines history, industry and business. The Amoskeag Millyard is home to The Millyard Museum, which tracks the history of what is now Manchester back 11,000 years. The Currier Museum of Art focuses on paintings by big names like Picasso and O'Keeffe. Head to the nearby town of Merrimack and visit the Anheuser-Busch Brewery, where guests can taste seasonal beers and see the famous Budweiser Clydesdale horses.

Natchez, the oldest settlement on the Mississippi River, has more antebellum houses than any other place in the United States. Many of these historic homes are open for tours. The friendly local people welcome visitors to their historic city with warm Southern charm. Tour the homes, the Grand Village of the Natchez and the Natchez Museum of African American History and Culture. Festivals and celebrations occur often throughout the year. For gamblers, the riverboat gaming experience is a fun and fascinating change from ordinary casinos. Active visitors will enjoy great golf, tennis, hiking, biking and fishing.

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

Wineries are beginning to rival the sweet-tasting Walla Walla onion as the hallmark of this lovely town at the foot of the Blue Mountains. In fact, the combination of excellent wineries and appealing scenery has put Walla Walla on the map as one of the country's hottest new wine-touring regions. The town's rich history, starting with the Indian tribes who first settled here followed by the early pioneers, the establishment and subsequent tragic demise of a famous mission and then a gold rush, is also a tourist draw. Fascinating museums and historic attractions bring this past to life. Music and the arts are a vital part of this culturally conscious college town, which boasts one of the oldest symphony orchestras west of the Mississippi, frequent summertime blues and jazz concerts, arts festivals and at least 15 art galleries. A revitalized downtown features restored 19th-century buildings, restaurants, galleries and wine-tasting rooms. If you're itching for outdoor fun, head east for hiking, mountain biking and fishing in the Blue Mountains or take the relatively easy Stateline Loop bike trail to Oregon and back.

This picturesque Umbrian city has a history that spans many eras. The city wall and arch are Etruscan; the sixth-century Sant'Angelo church was built atop a Roman temple; the town's cathedral is both Gothic and Renaissance. If you have a sweet tooth, visit the famous Perugina chocolate factory; if you have a full set of sweet teeth, visit during the Eurochocolate festival, held in October, when the entire town reportedly smells of chocolate.