Grindelwald is postcard-perfect, a charming example of a Swiss ski resort. There are slopes for all experience levels, plus plenty of snowy activities for those who don’t ski, such as sledding, hiking or snowshoeing. Not feeling particularly active? Just cozy up by crackling fire and enjoy the merry atmosphere. After a long day, nothing’s better than lingering over a pot of Swiss fondue and a glass of crisp wine as you plan the next day’s adventures.

Known as Padova in Italian, Padua may be the oldest city in northern Italy, if you believe the claims of its 12th-century BC founding by Trojans. It certainly has history, including its famous university (one of Europe’s oldest, from 1222), the 13th-century Basilica di Sant'Antonio (resting place of St. Anthony), and Scrovegni Chapel, with Giotto’s famed 14th century frescos. The magnificent Prato della Valle, a 950,000-square-foot elliptical square, is thought to be Europe’s second-biggest.

Glamourous Santorini is deliciously different. Geographical newness is in part to thank. The island’s popular black volcanic Perissa and Kamari beaches are big draws, as is its arguably most famous Red Beach near Akrotiri (which is the place to go for archaeology buffs). Santorini curves round a giant lagoon in the Cyclades islands, offering stunning views from sky-high towns, eclectic cuisine, lovely galleries, thriving nightlife and excellent wines.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Atmospheric backstreets paint a very different picture to first impressions of Abu Dhabi. The often slick and modern capital of the U.A.E. presents a fascinating mixture of tradition and progression. Tracing its rich history back to around 3000 B.C., Abu Dhabi maintains a more distinctly Arabian ambiance than glitzy Dubai. Taxis are a safe, reliable way to get around sites such as The Corniche Park, the White Fort, the Heritage Village, which offers glimpses into Bedouin life, and the Women's Craft Centre.

Lexington, Virginia, is a college town rich with history, charm and natural wonders. Surrounded by the breathtaking beauty of the Shenandoah Valley, its bustling downtown offers unique restaurants, artisan shops and galleries. Outdoor enthusiasts can enjoy mountain vistas on a walk along the Woods Creek trail or on a drive along the Blue Ridge Parkway. History buffs can follow the Civil War and visit the final resting places of iconic figures like Robert E. Lee and Stonewall Jackson.

The Zanzibar Archipelago, located in the Indian Ocean 15 miles off the coast of Tanzania, is a breathtaking spot to escape from the world. You’ll enjoy clear, turquoise-blue water; shallow sandbars perfect for wading; and many small, nearly deserted islands virtually unvisited by tourists. Explore the World Heritage Site of Stone Town, Zanzibar City’s old quarter. Or just go beach to beach between tiny fishing villages—each one's better than the next.