Perhaps best known these days as the setting for the book and movie “Under the Tuscan Sun,” gorgeous hillside Cortona has a long history dating back even before its time as an important Etruscan center. Top attractions include the Duomo (Cathedral), the small Museo Diocesano across the piazza with its superb art collection, and the fascinating Museo dell'Accademia Etrusca with its assembly of Etruscan and Roman era items. Cortona is also bursting with splendid churches spanning many periods.

Centrally located Umbria's principal cities include Spoleto, Assisi, and Terni. The capital, Perugia, is famed for its chocolate. Take a tour bus or prepare for daredevil Italian drivers if you opt to rent a car. Assisi's Basilica has a host of treasures, including works by Giotto. The town is also home to the crypt of St. Clare, patron saint of television. St. Francis' meditation retreat is in the mountains to the north. Classes at Velia's Cooking Style in Terni make good use of local produce.

On the south side of the Alps, Lake Maggiore is the second largest lake in Italy. Since the climate is mild year-round, the area is filled with Mediterranean vegetation and exotic plants. Lake Maggiore was featured in Ernest Hemingway's infamous novel, A Farewell to Arms, when the protagonist and his lover must row across the lake in order to escape the Italian Carabinieri (think police in military uniforms). Here's hoping you won't have any run-ins of that nature.

When most people think of Zermatt, they think of one thing: The Matterhorn. This ultimate Swiss icon looms over Zermatt, first drawing visitors here in the 1860s. The village of Zermatt itself is lovely and car-free, with old-fashioned brown chalets and winding alleys. (Don’t worry, you don’t have to walk everywhere—there are electric vehicles and horse-drawn cabs.) Skiing in the region often lasts through early summer, but when the weather’s warmer, it’s a great time to hike.

Lying in south central Turkey, the moonscaped region of Cappadocia, southeast of Ankara, is most famous for unique geological features called fairy chimneys. The large, cone-like formations were created over time by erosion of the relatively soft volcanic ash around them. Past cultures have dug into them to create dwellings, castles (like Uchisar) and even entire underground cities like Kaymakli and Derinkuyu, used as hiding places by early Christians. Nearby Kayseri is the gateway to the area.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.