You're on island time the moment you set foot in Jamaica. Ocho Rios, a port of call for many cruise lines, also boasts some of the most luxe resorts and spas in the Caribbean. And once you've had your stresses melted away in the island sun, you can head out for a night of dancing and reggae music.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."