Though Agrigento is a modern city of about 60,000 on Sicily’s southwest coast, the majority of visitors come to experience the past just outside of town. At the Valley of the Temples (Valle dei Templi), citizens of the then-major Greek colony of Akragras began building seven Doric style holy monuments in the sixth century BC. The nearby Archaeological Museum helps put everything into context. Agrigento also has some fascinating sights in its old town, like the medieval Norman cathedral.

To the first-time visitor, Palermo is a city of ever-changing character. An abundance of dusty museums, Arabian domes and flourishes of baroque splendor jostle with boisterous markets, chaotic traffic and oppressive summer heat. The Sicilian hotspot is a noisy, polluted, often dangerous, but always fascinating city. Don't miss marvels of Arab-Norman architecture, such as 12th-century Palazzo dei Normanni or San Giovanni degli Eremiti. Ask your hotel to arrange cabs and negotiate fares before setting off.

The Mediterranean's biggest island is separated from the mainland by the Strait of Messina. A mountainous spot, Sicily's coast and its small islands sit at the foot of volcanoes, including Etna, Stromboli and Vulcano. The Greeks, Romans, Normans and Catalans all left their mark on the island in the form of Byzantine palaces, Gothic castles and Baroque flourishes in capital Palermo. Most larger towns offer interesting museums, but Etna and the Hellenic temples in Agrigento offer particularly unique sights.