Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

Vines, wines and the people who love them are central to the economy of Napa Valley. Other treats for the taste buds are in store, too, in the form of local olive oils, tomatoes, cheeses and mustard. The other senses are catered for with a vibrant visual arts scene. Hire a car or book a taxi or limousine to travel safely between sights. The Napa Valley Wine Train offers an unusual way to experience the views and vintages. A relaxing array of spas and mud baths and the Old Faithful geyser are attractions in Calistoga.

Modern myth has it that these days everyone in Los Angeles has written a screenplay, is writing a screenplay or is just visiting. For those in the latter category we offer a road map of ideas to help make a trip to this ultra-hip, ultra-happening haven easy, fun and exciting. While LA will always be associated with movies and movie stars, it is also a culturally vibrant city that boasts a range of interesting attractions from prestigious art museums and galleries to fabulous theatre, both well-known productions and smaller fringe shows. Art enthusiasts will be stunned by the extensive collections at the J. Paul Getty Center and the Los Angeles County Museum of Art. Visit the La Brea Tar Pits on Museum Row, then investigate the trendy shops on Melrose Avenue. Families will not want to miss the zoo or the action at Universal Studios Hollywood. Of course, no trip to LA would be complete without a stop at the Venice Beach Boardwalk or a visit to Mann's Chinese Theater and the Walk of Fame.

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

What happens when a "gassy" Englishman rows into town feeling thirsty? A pub is born. And from that a city—in this case Vancouver. Though the pubs are plentiful, food and drink aren’t the only things to take in during your trip. In its 150 years, Vancouver has grown into a cosmopolitan city nestled in the great outdoors. Enjoy the snow-capped mountains, waterfront forests, cityside beaches, Olympic history and the world’s highest suspension bridge. Hipsters welcome. (Don’t worry, they don’t bite.)

Whistler, British Columbia, is a short trip from Vancouver by road or air. The stunning landscape, pedestrian-only Village and genuine, down-to-earth mountain culture make Whistler an unforgettable year-round destination. Winters provide reliable snow for skiing, snowboarding and Nordic sports while golf, mountain biking and hiking fill the warmer months. Festivals, spas, restaurants and bars combine with endless outdoor activities to make Whistler the ultimate place to escape and unwind.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.