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one day in Lyon on the way to Lake Geneva

We will be taking TGV from Avignon to Vevey, Switzerland late September. We would like to stopover one day and night in Lyon since neither my husband nor I have ever been there, considering it a "scouting trip" for a future visit. With so little time , where should we stay , what priority on sightseeing, and where should we eat? Efficiency is important and we prefer nice, charming hotels and restaurants.