As for all (your other) questions on itineraries - check with www.sbb.ch/en timetable application.
Almost 2h longer, more scenic route via Andermatt (with part of Glacier Express line from Brig). If looking for a long scenic trip you would have to travel over 2 days for Glacier Express Brig to St.Moritz, then Bernina Express to Tirano, bus to Lugano.
But if you can arrange to have a little more time, the ride via Simplon, Domodossola and the Centovalli is rather special. You'll have to change trains a couple of times and it's slower, but the views are extraordinary.
Thank you. Would I have to buy separate tickets for each leg of the train ride?Edited: 10 June 2018, 22:32