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The closest airport is the Tri-Cities Regional Airport located in Blountville, TN. Serviced by Delta, US Air, and Northwest, this airport is just 3 miles off Interstate 81. From there it's about a 35-minute drive to Abingdon, VA. Just hop on 81 and go.
Car rentals are available at the airport. There is also taxi and limosine service.
From anywhere in Virginia and points north, tourists will head for Interstate 81 south. For a more leisurely drive from the eastern part of the state, Route 58 west is pleasant.
From Knoxville, Tennessee, take Interstate 40 east to Interstate 81 north.
From Winston-Salem, North Carolina, take Interstate 85 to 77 north to Interstate 81 south.